Made to do more.

Mirrors native lung surfactant.

Infasurf® (calfactant) resembles native calf lung surfactant in both composition and activity due to our lung lavage manufacturing process.

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Native Lung Surfactant1

41% Disaturated Phosphatidylcholine (DSPC)
10% Phosphatidyl Glycerol (PG)
5% Cholesterol (Chol)
4% Other Phospholipids (PLS)
9% SP-A
2% SP-B, SP-C
29% Unsaturated Phosphatidylcholine (USPC)

Infasurf® (calfactant)2

Infasurf® (calfactant) is native calf lung surfactant without SP-A
Same % of SP-B to total phospholipids
Retains natural cholesterol level

Infasurf Bottle
  • All essential components of native calf lung surfactant are maintained in Infasurf® (calfactant) due to our unique lavage manufacturing process3
  • Surfactant protein B (SP-B) is essential for forming the surfactant film that lines the alveoli4,5
  • Infasurf® (calfactant) is the only surfactant that retains natural cholesterol, which aids the rapid spread of the surfactant film during respiration6

References:

1. Notter RH. Lung Surfactants. Michael Dekker, New York, 2000, pp 171-232; 319-345. 2. Swartz D, Klein W, Row S, et al. Comparison of dynamic viscosities of lung surfactant drugs. Poster presented Hot Topics. 3. Component-specific surface and physiological activity in bovine-derived lung surfactants H Notter a b c, Z Wang a, E.A Egan d e, B.A Holm d f Chemistry and Physics of Lipids Volume 114, Issue 1, January 2002, Pages 21-34 4. Mizuno K, Ikagami M, Chen C-M, et al. Surfactant protein-B supplementation improves in vivo function of a modified natural surfactant. Pediatr Res. 1995;37:271-276. 5. Hall SB, Vemkitaraman AR, Whitsett JA, et al. Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants. Am Rev Respir Dis. 1992;145:24-30. 6. Kim K, Choi S, Zell Z, et al. Effect of cholesterol nanodomains on monolayer morphology and dynamics. Proc Natl Acad Sci USA. 2013;110:E3054-60.

Safety Information:

Infasurf (calfactant) should be administered under the supervision of clinicians experienced in the acute care of newborn infants with respiratory failure who require intubation. Rapid and substantial increases in blood oxygenation and improved lung compliance often follow Infasurf instillation/ Close clinical monitoring and surveillance following administration may be needed to adjust oxygen therapy and ventilator pressures appropriately.