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Infasurf® (calfactant) has lower dynamic viscosity.2

Low resistance to flow (dynamic viscosity) may improve the uniformity of distribution in the lung.

Dynamic Viscosities of Lung Surfactants2

Normal Saline
Infasurf© (calfactant)
Curosurf© (poractant alfa)
Survanta© (beractant)
High SP-B to phospholipid ratio
  • Infasurf’s unique composition and low viscosity allows for fast distribution to the distal airways2.
  • At room and body temperature, Infasurf has lower dynamic viscosity than Curosurf®(poractant alfa) and Survanta®(beractant)2.
  • Dynamic viscosity is only slightly changed by temperature

Approximate Dynamic Viscosities of Common Substances7,8

Infasurf Viscosities Chart

Disclaimer:

There are no prospective, randomized clinical trials comparing Infasurf® and Curosurf® with respect to safety or efficacy.

References:

2. Swartz D, Klein W, Row S, et al. Comparison of dynamic viscosities of lung surfactant drugs. Poster presented Hot Topics. 2017. 7. Infasurf® (calfactant) Intratracheal Suspension Prescribing Information, ONY Biotech, March 2018. 8. Curosurf® (poractant alfa) Intratracheal Suspension Prescribing Information, Chiesi USA, Inc. December 2014.